Our Plan

The Canadian HIV Observational Cohort (CANOC) Collaborative Research Centre focuses on HIV health services and epidemiologic cohort research.

We aim to place Canadian HIV/AIDS research on par with existing international efforts. This national collaboration conducts policy-relevant studies in HIV therapeutics, population and public health. The CANOC Centre brings together a diverse team to capitalize on the unique and robust CANOC database, maximizing the quality and breadth of the health services and policy research generated.

The CANOC cohort, which consists of eleven clinical cohorts from British Columbia, Ontario, Quebec, Saskatchewan and Newfoundland and Labrador, provides researchers with the analytic power to conduct large and detailed analyses of HIV treatment outcomes that would not be possible within individual cohorts. In the upcoming years, we will continue to address gaps in our understanding of treatment outcomes and regional trends within Canada, informing best practice guidelines for treatment of HIV, and contributing to the training of exceptional new scholars and community investigators.

clinic and population-based cohort databases from British Columbia, Saskatchewan, Ontario, Quebec, and Newfoundland

Inclusion criteria

  • Initiated 3+ antiretroviral drugs on or after Jan 1, 2000 with no prior antiretroviral experience
  • Aged 18 years or older
  • Resident of Canada
  • Baseline CD4 cell count and viral load measurements within 6 months of antiretroviral initiation

Enrollment period

Jan 1, 2000 to Dec 31, 2016


  • Ethics approval for CANOC was granted by the harmonized Simon Fraser University Research Ethics Board and the University of British Columbia Research Ethics Board
  • Approval from local institutional review boards was granted at each participating site

CANOC Objectives

The overall objectives are to

Grow and Support

Grow and support a virtual national Centre that will foster longitudinal pan-provincial collaborative HIV and health services cohort research.


Expand Canada’s largest longitudinal HIV treatment cohort of HIV-positive individuals accessing antiretroviral therapy to additional regions of Canada


Conduct multidisciplinary health services research for people living with HIV in Canada that is responsive to key populations most affected by HIV, focused on the delivery of high quality and cost-efficient care, and with a strong consideration of the impact of aging on health outcomes and health service needs.


Promote collaborative and meaningful relationships between researchers and knowledge users


Engage in knowledge translation and exchange to disseminate key research findings and generate policy/practice recommendations at the provincial, national, and international levels.


Establish and maintain a productive training environment for new HIV researchers and community members
  • Age
  • Sex
  • Ethnicity
  • Province
  • Postal code
  • HIV risk factor
  • Year of entry into cohort
  • Treatment start date
  • HIV viral load
  • CD4 cell count
  • AIDS-defining illness
  • HCV co-infection
  • Antiretroviral therapy class and active ingredient
  • Antiretroviral therapy start and stop date
  • Combination product name (brand)

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